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Para que sirve el prednisone
Infections in patients affected by rheumatologic diseases associated to glucocorticoid use or tumor necrosis factor-alpha inhibitors. Hospital Militar de Santiago, Chile. Departamento de Medicina. Financiamiento: ninguno. Correspondencia a :. Overlapping agents include intracellular bacteria, Mycobacterium tuberculosis, geographic fungal agents that have the ability to establish granulamotous infections, herpes zoster, and reactivation of chronic hepatitis B virus infection.
An important conceptual issue for these infections is the existence of a threshold prednisone daily dose for the emergence of opportunistic infections but higher levels of immunosuppression and cofactors are required in the case of Pneumocystis jiroveci and cytomegalovirus infections.
In order to prevent these threats, a detailed medical evaluation is needed before prescription to detect potential risks and manage them properly. Prevention rules must be prescribed in every case, that include common sense behaviors, vaccines, and in selected cases, chemoprophylaxis for latent tuberculosis TB infection, P.
Latent TB infection is probable and requires chemoprophylaxis in the case of remote or recent exposure to a patient with lung TB, a positive tuberculin or interferon-gamma release assay result or residual lung scars in a chest x-ray exam.
PCP prevention is suggested when the patient reaches a daily dose of prednisone of 30 mg but might be needed at lower doses in case of other concomitant immunosuppressive drugs or when lymphopenia arises shortly after prednisone initiation. Key words: Infection, glucocorticoids, tumor necrosis factor-alpha, rheumatoid arthritis, systemic lupus erythematosus, interferon-gamma release tests, tuberculosis.
Implican una gran carga de morbilidad adicional y en ocasiones son letales. Infecciones asociadas a corticosteroides. Las infecciones oportunistas asociadas a glucocorticoides aparecen cuando se asegura una dosis umbral. Una diversidad de agentes comunes u oportunistas se asocia a infecciones en pacientes que reciben dosis inmunosupresoras de corticosteroides Tabla 1 6. Tabla 1. Agentes infecciosos en pacientes inmunosuprimidos por corticosteroides.
Las enterobacterias, Staphylococcus spp y Streptococcus spp participan en infecciones habituales del tracto urinario, de piel o tejidos blandos o cuadros de bacteriemia. La TBC en estos pacientes se presenta como cuadros pulmonares y con una alta frecuencia como formas extra-pulmonares Aunque no es claro si los glucocorticoides aumentan el riesgo de diarrea por C.
Las infecciones del SNC por C. Pneumocystis jiroveci es un hongo oportunista que se asocia a infecciones en pacientes que reciben corticosteroides. Los casos de mucormicosis reportados en Chile no se han asociado a este tipo de pacientes Este agente parasitario se adquiere por la ingesta de carne contaminada inapropiadamente cocida o contacto con heces de gatos Una serie de protozoos intestinales tienen el potencial de afectar pacientes inmunosuprimidos por glucocorti-coides 6, La tasa fue de 42 eventos graves por 1.
La tasa de incidencia de infecciones oportunistas es elevada llegando a valores superiores a por Tabla 2. En ocasiones se han descrito cuadros de artritis Los cuadros de TBC incluyen formas diseminadas o extrapulmonares El riesgo parece muy inferior en los usuarios de etarnecept 3 por Etanercept no aparece asociado a un mayor riesgo.
Este riesgo no se observa en casos de hepatitis por VHC Tabla 3. Tabla 4. Consumo de agua y alimentos seguros. Tabla 5. Tabla 6. Contacto con personas afectadas por enfermedades contagiosas. Tabla 7. Contacto con mascotas. Tabla 8. Estas medidas son importantes de adoptar ya que los pacientes inmunosuprimidos tienen con frecuencia mascotas, las que tienen un bajo porcentaje de control veterinario, son portadoras de condiciones de riesgo para el paciente y los pacientes tienen conductas con ellas que los exponen a diferentes enfermedades graves No se han detectado diferencias de acuerdo al antagonista utilizado en estos pacientes.
Figura 1. Riesgo de tuberculosis-TBC activa durante toda la vida en diferentes situaciones. Datos adaptados de referencia Los corticosteroides y otros inmunosupresores aumentan el porcentaje de pruebas IGRAs con un valor indeterminado.
Se reconoce que las pruebas IGRAs tienen mayor especificidad y el potencial de exponer a menos pacientes innecesariamente a quimioprofilaxis respecto a la prueba de tuberculina.
En caso de aplicarse la prueba de tuberculina, debe ser aplicada una segunda vez en caso de un primer resultado negativo El riesgo de hepatitis por isoniazida se concentra en los primeros 9 meses y alcanza los 5 casos por 1.
Puede presentar anticuerpos anti-histonas pero, a diferencia del LES, no se asocia a anticuerpos anti ADN de doble cadena Tabla 9. Tabla Resumen de medidas preventivas. Si un paciente recibe ambos compuestos, se deben considerar las medidas para el subgrupo con corticosteroides.
Figura 2. La quimioprofilaxis para P. El uso de terapias modificantes no aparece como un factor de riesgo en mortalidad pero los anti-inflamatorios no esteroidales generan muertes por hemorragia digestiva. Glucocorticoids and invasive fungal infections.
Lancet ; Risk of complications in patients taking glucocorticosteroids. Rev Infect Dis ; Ann Rheum Dis ; JAMA ; Adverse events of low- to medium-dose oral glucocorticoids in inflammatory diseases: a meta-analysis.
Infections associated with steroid use. Infect Dis Clin North Am ; Infections in 96 cases of systemic lupus erythematosus. Med Clin Barc ; Epidemiology and clinical outcomes of bloodstream infections among lupus patients. Lupus ; Long-term outcome and short-term survival of patients with systemic lupus erythematosus after bacteraemia episodes: 6-yr follow-up.
Rheumatology ; The epidemiology of and risk factors for invasive Staphylococcus aureus infections in western Sweden. Scand J Infect Dis ; Emergencia de infecciones por Enterococcus sp resistente a vancomicina en un hospital universitario en Chile. Rev Chilena Infectol ; Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases. J Microbiol Immunol Infect ; Infecciones por Listeria monocytogenes. Rev Chilena Infectol ; 30 4 : Glucocorticoid use, other associated factors, and the risk of tuberculosis.
Arthritis Rheum ; Tuberculosis infection in patients with systemic lupus erythematosus: pulmonary and extra-pulmonary infections compared. Clin Rheumatol ; Nocardia neocaldoniensis as a cause of skin and soft tissue infection.
J Clin Microbiol ; Cerebral nocardiosis. J Pak Med Assoc ; Nocardiosis in patients with systemic lupus erythematosus. J Rheumatol ; Rev Med Chile ; Glucocorticoids are associated with increased risk of short-term mortality in hospitalized patients with Clostridium difficile-associated disease.
Am J Gastroenterol ; Rheumatoid arthritis and the incidence of influenza and influenza-related complications: a retrospective cohort study. BMC Musculoskelet Disord ; Early use of glucocorticoids was a risk factor for critical disease and death from pH1N1 infection.
❿Para que sirve el prednisone -
Para que sirve el prednisone -
You may report side effects to Health Canada at Before taking prednisone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:. Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products.
This medication may mask signs of infection. It can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others such as chickenpox, measles, flu. Consult your doctor if you have been exposed to an infection or for more details. Ask your doctor or pharmacist about using this product safely.
Avoid contact with people who have recently received live vaccines such as flu vaccine inhaled through the nose. This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Consult your doctor or pharmacist for more information.
This medication may slow down a child's growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child's height and growth can be checked. During pregnancy, this medication should be used only when clearly needed. It may rarely harm an unborn baby.
Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems. This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Palabras clave:. Objectives To assess the efficacy and tolerability of oral deflazacort versus oral prednisolone in acute moderate asthma in children. Patients and methods We performed a prospective, randomized, parallel group trial of children aged 6 to 14 years old with a diagnosis of asthma who presented to the pediatric emergency department for moderate asthma exacerbation. Patients were evaluated at the start of treatment visit 1 , on day 2 visit 2 and on day 7 visit 3. Results Of the 54 children enrolled, two were hospitalized on visit 2 one from each group.
No adverse effects were reported. Conclusions Deflazacort and prednisolone show similar efficacy in improving pulmonary function and in producing clinical improvement in the management of acute moderate asthma in children. Key words:. Mannino, D. Homa, C. Pertowski, A. Ashizawa, L. Nixon, C. Johson, et al. Surveillance from asthma-United States, Qureshi, A. Zaritsky, M. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma.
J Pediatr, , pp. Decreases in asthma mortality in the United States. Ann Allergy Asthma Immunol, 85 , pp. Canny, J. Reisman, R. Healy, C. Schwartz, C. Petrou, A. Rebuck, et al. Acute asthma: Observations regarding the management of a pediatric emergency room. Pediatrics, 83 , pp. Murphy, H. Advances in the management of acute asthma in children. Pediatr Rev, 17 , pp.
Treating exacerbations of asthma in children: The role of systemic corticosteroids. Pediatrics, , pp. Rowe, C. Spooner, F. Ducharme, J. Bretzlaff, G. Rheumatology Oxford ; Clinical significance of enteric protozoa in the immunosuppressed human population. Clin Microb Rev ; Amoebic colitis exacerbated by steroids. Br Med J Jul 19; 3 : Amoebic dysentery precipitated by corticosteroids.
Br Med J ; 3 : Relapsing amoebic colitis of 12 years' standing exacerbated by corticosteroids. Br Med J ; 2: Overwhelming watery diarrhea associated with a cryptosporidium in an immunosuppressed patient.
Gastroenterology ; Infectious complications associated with immunomodulating biological agents. Hematol Oncol Clin North Am ; Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Reumathology Biologics Register with special emphasis on risk in the elderly.
Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register. Clin Infect Dis ; e Listeria infection in patients on anti-TNF treatment: report of two cases and review of the literature.
J Crohns Colitis ; 7: Biologics and infections: lessons from tumor necrosis factor blocking agents. Granulomatous infections due to tumor necrosis factor blockade. Risk of tuberculosis in patients treated with tumor necrosis factor antagonists due to incomplete prevention of reactivation of latent infection. Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy. Drugs ; Chronic hepatitis B reactivation following infliximab therapy in Crohn's disease patients: need for primary prophyalxis.
Gut ; Intensified, intermittent, low-dose intravenous cyclosphosphamide together with oral alternate-day steroid therapy in lupus nephritis long-term outcome. Long-term outcome of polymyositis treated with high single-dose alternate-day prednisolone therapy. Eur Neurol ; Comparison of daily and alternate-day prednisone during chronic maintenance therapy: a controlled crossover study. Am J Kidney Dis ; 1: Alternate-day single-dose prednisone therapy: a method of reducing steroid toxicity.
J Pediatr Surg ; 7: Alternate-day prednisone therapy. Evaluation of delayed hypersensitivity responses, control of disease and steroid side effects. N Engl J Med ; Alternate-day prednisone. Leukocyte kinetics and susceptibility to infections.
TNF blockers show distinct patterns of immune response to the pandemic influenza A H1N1 vaccine in inflammatory arthritis patients. The effect of anti-tumor necrosis factor alpha treatment on the antibody response to influenza vaccination. Clin Exp Rheumatol ; 30 1 Suppl 70 : S Influence of methotrexate, TNF blockers and prednisolone on antibody responses to pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis.
Antibody response is reduced following vaccination with 7-valent conjugate pneumococcal vaccine in adult methotrexate-treated patients with established arthritis, but not those treated with tumor necrosis factor inhibitors.
Heptavalent pneumococcal conjugate vaccine elicits similar antibody response as standard valent polysaccharide vaccine in adult patients with RA treated with immunomodulating drugs. Persistence of antibody response 1. Arthritis Res Ther ; R1. Immunogenicity and safety of pneumococcal vaccination in patients with rheumatoid arthritis or systemic lupus erythematosus.
Bacteremic pneumococcal pneumonia: serotype distribution, antimicrobial susceptibility, severity scores, risk factors and mortality in a single centre in Chile. Revaccination with pneumococcal vaccine of elderly persons 6 years after primary vaccination.
Vaccine ; 9: Revaccination with the valent pneumococcal polysaccharide vaccine in middle-aged and elderly persons previously treated for pneumonia. Vaccine ; Safety of revaccination with pneumococcal polysaccharide vaccine.
Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults: conjugate vaccine elicits improved antibacterial immune responses and immunological memory. Immunogenicity of varying dosages of 7-valent pneumococcal polysaccharide-protein conjugate vaccine in seniors previously vaccinated with valent pneumococcal polysaccharide vaccine. How to reduce morbidity and mortality from chest infections in rheumatoid arthritis.
Clin Med ; Priorities for the treatment of latent tuberculosis infection in the United States. Your doctor may also prescribe or recommend a calcium or potassium supplement. Follow these directions carefully. Talk to your doctor about eating grapefruit and drinking grapefruit juice while you are taking this medication. When you start to take prednisone, ask your doctor what to do if you forget to take a dose.
Write down these instructions so that you can refer to them later. Call your doctor or pharmacist if you miss a dose and do not know what to do.
Do not take a double dose to make up for a missed dose. Prednisone may slow growth and development in children. Your child's doctor will watch his or her growth carefully.
Talk to your child's doctor about the risks of giving prednisone to your child. Prednisone may increase the risk that you will develop osteoporosis. Talk to your doctor about the risks of taking prednisone and about things that you can do to decrease the chance that you will develop osteoporosis.
Some patients who took prednisone or similar medications developed a type of cancer called Kaposi's sarcoma. Talk to your doctor about the risks of taking prednisone. Prednisone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
However, you should not flush this medication down the toilet.
Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels lack of certain substances that are usually produced by the body and are needed for normal body functioning. Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis a disease in which the nerves do not function properly ; lupus a disease in which the body attacks many of its own organs ; and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines.
Prednisone is also sometimes used to treat the symptoms of certain types of cancer. Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works. Prednisone comes as a tablet, delayed-release tablet, as a solution liquidand as a concentrated solution to take by mouth.
Prednisone is usually taken with food one to four times a day or once every other day. Your doctor will probably tell you to take your dose s of prednisone at certain time s of day every day. Your personal dosing schedule will depend on your condition and on how you respond to treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take prednisone exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.
If you are taking the concentrated solution, use the specially marked dropper that comes with the medication to measure your dose. You may mix the concentrated solution with juice, other flavored liquids, or soft foods such as applesauce.
Your doctor may change your dose of prednisone often during your treatment to be sure that you are always taking the lowest dose that works for you. Your doctor may also need to change your dose if you experience unusual stress on your body such as surgery, illness, infection, or a severe asthma attack.
Tell your doctor if your symptoms improve or get worse or if you get sick or have any changes in your health during your treatment.
If you are taking prednisone to treat a long-lasting disease, the medication may help control your condition but will not cure it. Continue to take prednisone even if you feel well. Do not stop taking prednisone without talking to your doctor. If you suddenly stop taking prednisone, your body may not have enough natural steroids to function normally.
This may cause symptoms such as extreme tiredness, weakness, slowed movements, upset stomach, weight loss, changes in skin color, sores in the mouth, and craving for salt. Call your doctor if you experience these or other unusual symptoms while you are taking decreasing doses of prednisone or after you stop taking the medication. Prednisone is also sometimes used with antibiotics to treat a certain type of pneumonia in patients with acquired immunodeficiency syndrome AIDS.
Talk to your doctor about the risks of using this drug for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Your doctor may instruct you to follow a low-salt, high potassium, or high calcium diet. Your doctor may also prescribe or recommend a calcium or potassium supplement. Follow these directions carefully. Talk to your doctor about eating grapefruit and drinking grapefruit juice while you are taking this medication.
When you start to take prednisone, ask your doctor what to do if you forget to take a dose. Write down these instructions so that you can refer to them later. Call your doctor or pharmacist if you miss a dose and do not know what to do. Do not take a double dose to make up for a missed dose.
Prednisone may slow growth and development in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor about the risks of giving prednisone to your child. Prednisone may increase the risk that you will develop osteoporosis. Talk to your doctor about the risks of taking prednisone and about things that you can do to decrease the chance that you will develop osteoporosis.
Some patients who took prednisone or similar medications developed a type of cancer called Kaposi's sarcoma. Talk to your doctor about the risks of taking prednisone. Prednisone may cause other side effects.
Call your doctor if you have any unusual problems while you are taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory.
Your doctor will order certain lab tests to check your body's response to prednisone. If you are having any skin tests such as allergy tests or tuberculosis tests, tell the doctor or technician that you are taking prednisone. Do not let anyone else take your medication.
Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
It is also important information to carry with you in case of emergencies. Generic alternatives may be available. Prednisone pronounced as pred' ni sone. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow?
What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names. Swallow the delayed-release tablet whole; do not chew or crush it. Other uses for this medicine.
What special precautions should I follow? Before taking prednisone, tell your doctor and pharmacist if you are allergic to prednisone, any other medications, or any of the inactive ingredients in prednisone tablets or solutions. Ask your doctor or pharmacist for a list of the inactive ingredients. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. John's wort. If you become pregnant while taking prednisone, call your doctor.
You should carry a card or wear a bracelet with this information in case you are unable to speak in a medical emergency. Stay away from people who are sick and wash your hands often while you are taking this medication. Be sure to avoid people who have chicken pox or measles. Call your doctor immediately if you think you may have been around someone who had chicken pox or measles. Prednisone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache dizziness difficulty falling asleep or staying asleep inappropriate happiness extreme changes in mood changes in personality bulging eyes acne thin, fragile skin red or purple blotches or lines under the skin slowed healing of cuts and bruises increased hair growth changes in the way fat is spread around the body extreme tiredness weak muscles irregular or absent menstrual periods decreased sexual desire heartburn increased sweating Some side effects can be serious.
If you experience any of the following symptoms, call your doctor immediately: vision problems eye pain, redness, or tearing sore throat, fever, chills, cough, or other signs of infection seizures depression loss of contact with reality confusion muscle twitching or tightening shaking of the hands that you cannot control numbness, burning, or tingling in the face, arms, legs, feet, or hands upset stomach vomiting lightheadedness irregular heartbeat sudden weight gain shortness of breath, especially during the night dry, hacking cough swelling or pain in the stomach swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs difficulty breathing or swallowing rash hives itching Prednisone may slow growth and development in children.
What other information should I know? Browse Drugs and Medicines.
Prednisolone se usa en el tratamiento de varias diferentes condiciones, como la artritis, lupus, psoriasis, colitis ulcerativa, trastornos de alergias. Para que sirve el medicamento bersen prednisone 20 mg. Prednisone is a corticosteroid and short-acting bronchodilator that is used to treat conditions such. La lista de microorganismos participantes es más restringida en el caso de los Para pacientes con dosis equivalentes hasta 30 mg al día de prednisona. La PREDNISONA trata muchas afecciones tales como asma, reacciones alérgicas, artritis, enfermedades intestinales inflamatorias, problemas suprarrenales. Best quality prednisone 10 mg tablet para que sirve shipping. Order today $ x tablet prednisone 40 mg e-check. Ann Dermatol Venereol ; 4 Pt 1 : Pulos, E. Smith, R. Los corticosteroides y otros inmunosupresores aumentan el porcentaje de pruebas IGRAs con un valor indeterminado. Oral versus intravenous corticosteroids in children hospitalized with asthma. Pediatr Rev, 17pp. Lancet, 1pp.To assess the efficacy and tolerability of oral deflazacort versus oral prednisolone in acute moderate asthma in children..
We performed a prospective, randomized, parallel group trial of children aged 6 to 14 years old with a diagnosis of asthma who presented to the pediatric emergency department for moderate asthma exacerbation. The intervention groups received either oral deflazacort 1. Patients were evaluated at the start of treatment visit 1 , on day 2 visit 2 and on day 7 visit Of the 54 children enrolled, two were hospitalized on visit 2 one from each group.
No adverse effects were reported.. Deflazacort and prednisolone show similar efficacy in improving pulmonary function and in producing clinical improvement in the management of acute moderate asthma in children.. ISSN: Exportar referencia. DOI: Comparative efficacy of oral deflazacort versus oral prednisolone in children with moderate acute asthma. Descargar PDF. Gartner a ,. Autor para correspondencia.
Hospital Donostia. Palabras clave:. Objectives To assess the efficacy and tolerability of oral deflazacort versus oral prednisolone in acute moderate asthma in children. Patients and methods We performed a prospective, randomized, parallel group trial of children aged 6 to 14 years old with a diagnosis of asthma who presented to the pediatric emergency department for moderate asthma exacerbation.
Patients were evaluated at the start of treatment visit 1 , on day 2 visit 2 and on day 7 visit 3. Results Of the 54 children enrolled, two were hospitalized on visit 2 one from each group. No adverse effects were reported. Conclusions Deflazacort and prednisolone show similar efficacy in improving pulmonary function and in producing clinical improvement in the management of acute moderate asthma in children.
Key words:. Mannino, D. Homa, C. Pertowski, A. Ashizawa, L. Nixon, C. Johson, et al. Surveillance from asthma-United States, Qureshi, A. Zaritsky, M. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr, , pp. Decreases in asthma mortality in the United States.
Ann Allergy Asthma Immunol, 85 , pp. Canny, J. Reisman, R. Healy, C. Schwartz, C. Petrou, A. Rebuck, et al. Acute asthma: Observations regarding the management of a pediatric emergency room. Pediatrics, 83 , pp. Murphy, H.
Advances in the management of acute asthma in children. Pediatr Rev, 17 , pp. Treating exacerbations of asthma in children: The role of systemic corticosteroids. Pediatrics, , pp. Rowe, C. Spooner, F. Ducharme, J. Bretzlaff, G. Early emergency department treatment of acute asthma with systemic corticosteroids. Cochrane Database Syst Rev, , pp. CD Expert Panel Report 2: Guidelines for the diagnosis and management of asthma. British Thoracic Society Guidelines for managing asthma in adults and children.
Thorax, 52 , pp. Management of patients with asthma in the emergency department and in hospital. CMAJ, , pp. Global Strategy for Asthma Management and Prevention. Plaza, F. Cobos, A. Llauger, et al.
Arch Bronconeumol, 39 , pp. Corticosteroids for preventing relapse following acute exacerbations of asthma Cochrane Review. En: The Cochrane Library. Issue 3. Markham, H. Drugs, 50 , pp. Estudio comparativo de la eficacia de dos corticoides orales en el control de la crisis grave de asma bronquial: Deflazacort y prednisona.
Rev Alerg Mex, 42 , pp. Definitions and classification of chronic bronchitis, asthma, and pulmonary emphysema. Am Rev Respir Dis, 85 , pp. Arch Bronconeumol, 25 , pp. Smith, R. Emerg Med, 46 , pp. J Pediatr, 96 , pp. Streetman, V. Bhatt-Metha, C. Management of acute, severe asthma in children.
Ann Pharmacother, 36 , pp. Storr, E. Barrell, W. Barry, W. Lenney, G. Effect of a single oral dose of prednisolone in acute childhood asthma. Lancet, 1 , pp. Scarfone, S. Fuchs, A. Nager, S. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics, 92 , pp. Tang, S. Soluble interleukin-2 receptor and interleukin- 4 in sera of asthmatic children before and after a prednisolone course. Ann Allergy Asthma Immunol, 86 , pp.
Gibson, M. Norzila, K.
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